Close this search box.

We are creating some awesome events for you. Kindly bear with us.

NUS researchers create STAMP technology – a less invasive biopsy procedure

Image credits:

A team of researchers from NUS have created a new technology that is able to accurately identify and classify cancer cells.

Called the Sequence-Topology Assembly for Multiplexed Profiling (STAMP), this technology is also able to predict the aggressiveness of the disease. It is an upgraded version of the current biopsy process.

With this technology, detailed information of the disease can be obtained at a much faster rate and at a much earlier stage too.

A typical biopsy involves the removal of small amounts of tissue from the body. These tissues will then be analysed by doctors for diagnosing cancers.

This is an invasive procedure but the lack of it will lead to a lack of samples which will result in inaccurate diagnosis of the disease. A confirmed diagnosis of the cancer, however, can only be made post-surgery which takes time to obtain.

This new STAMP technology is a solution to all these obstacles. This technology works by using programmable DNA barcodes for measuring billions of protein markers within a single test. It will measure the amount of protein markers and the distribution of it in a cell.

The DNA is folded into 3D nanostructures for achieving a high labelling efficiency and to remain strong against biological degradation. STAMP utilises the two properties of DNA which are the large capacity to store information and the programmability to fold and unfold different structures.

The 3D barcodes are unfolded on-demand via heating for conducting analysis.

“To perform analysis, these 3D barcodes are unfolded on-demand through heating to release a pool of linear DNA, which can be easily analysed using established technologies such as PCR and DNA sequencing. In this way, the expression of a very large number of protein markers and their distribution in cells can be sensitively measured in a single test,” said Mr Noah Sundah, doctoral student from NUS iHealthtech as well as NUS Biomedical Engineering, and first author of the study.

STAMP achieved a high diagnostic accuracy of above 94 per cent for diagnosis of breast cancer. It also provided crucial clinical information which is usually obtained post-surgery. This is the result of a clinical study done by the research team.

The clinical study constituted 69 breast cancer patients.

Free needle aspiration (FNA) biopsies of every patient were obtained from every patient and these samples were analysed using STAMP.

A similar procedure was done but using gold-standard pathology analysis on post-surgery tissues of the patients.

As mentioned earlier, the results showed high levels of accuracy and were on the same accuracy level as the gold-standard pathology analysis.

The 10-member research team was led by Assistant Professor Shao Huilin from the NUS Institute for Health Innovation & Technology (NUS iHealthtech).

It has goals of expanding the application of STAMP to other forms of cancer such as brain, lung and gastric.


Qlik’s vision is a data-literate world, where everyone can use data and analytics to improve decision-making and solve their most challenging problems. A private company, Qlik offers real-time data integration and analytics solutions, powered by Qlik Cloud, to close the gaps between data, insights and action. By transforming data into Active Intelligence, businesses can drive better decisions, improve revenue and profitability, and optimize customer relationships. Qlik serves more than 38,000 active customers in over 100 countries.


CTC Global Singapore, a premier end-to-end IT solutions provider, is a fully owned subsidiary of ITOCHU Techno-Solutions Corporation (CTC) and ITOCHU Corporation.

Since 1972, CTC has established itself as one of the country’s top IT solutions providers. With 50 years of experience, headed by an experienced management team and staffed by over 200 qualified IT professionals, we support organizations with integrated IT solutions expertise in Autonomous IT, Cyber Security, Digital Transformation, Enterprise Cloud Infrastructure, Workplace Modernization and Professional Services.

Well-known for our strengths in system integration and consultation, CTC Global proves to be the preferred IT outsourcing destination for organizations all over Singapore today.


Planview has one mission: to build the future of connected work. Our solutions enable organizations to connect the business from ideas to impact, empowering companies to accelerate the achievement of what matters most. Planview’s full spectrum of Portfolio Management and Work Management solutions creates an organizational focus on the strategic outcomes that matter and empowers teams to deliver their best work, no matter how they work. The comprehensive Planview platform and enterprise success model enables customers to deliver innovative, competitive products, services, and customer experiences. Headquartered in Austin, Texas, with locations around the world, Planview has more than 1,300 employees supporting 4,500 customers and 2.6 million users worldwide. For more information, visit


SIRIM is a premier industrial research and technology organisation in Malaysia, wholly-owned by the Minister​ of Finance Incorporated. With over forty years of experience and expertise, SIRIM is mandated as the machinery for research and technology development, and the national champion of quality. SIRIM has always played a major role in the development of the country’s private sector. By tapping into our expertise and knowledge base, we focus on developing new technologies and improvements in the manufacturing, technology and services sectors. We nurture Small Medium Enterprises (SME) growth with solutions for technology penetration and upgrading, making it an ideal technology partner for SMEs.


HashiCorp provides infrastructure automation software for multi-cloud environments, enabling enterprises to unlock a common cloud operating model to provision, secure, connect, and run any application on any infrastructure. HashiCorp tools allow organizations to deliver applications faster by helping enterprises transition from manual processes and ITIL practices to self-service automation and DevOps practices. 


IBM is a leading global hybrid cloud and AI, and business services provider. We help clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Nearly 3,000 government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and business services deliver open and flexible options to our clients. All of this is backed by IBM’s legendary commitment to trust, transparency, responsibility, inclusivity and service.