Search
Close this search box.

We are creating some awesome events for you. Kindly bear with us.

Indonesia: Digital Radiopharmaceuticals for Cancer Care

Getting your Trinity Audio player ready...

The National Research and Innovation Agency (BRIN), in collaboration with the PET Imaging Centre at the University Hospital of Northern Norway (PET IC UNN), is harnessing advanced digital technology to develop a fibroblast-activated protein inhibitor (FAPI). This cutting-edge radioligand holds significant promise for improving cancer diagnosis and therapy.

Image credits: brin.go.id

The collaboration sees BRIN focusing on the synthesis of FAPI ligands, leveraging their expertise in radiopharmaceutical research. Norway, on the other hand, will conduct in-vitro and in-vivo imaging, utilising their advanced molecular imaging technology.

According to PRTRRB BRIN Research Associate Expert Rien Ritawidya, this initiative is part of a broader effort to reduce cancer morbidity and mortality through a comprehensive national cancer control programme. This programme includes prevention, early detection, diagnosis, and appropriate treatment of cancer, recognising the critical role of early intervention in improving patient outcomes.

Early detection and diagnosis are essential components in the fight against cancer. Protein activation in fibroblast activating protein (FAP) represents a critical target for cancer diagnosis and therapy. Numerous imaging agents targeting FAP are currently in clinical trial stages. For instance, FAPI-46 has demonstrated an increased tumour-to-background ratio, significantly enhancing the quality of imaging.

The collaboration aims to develop various types of FAPI that could be further optimised as theranostic agents, combining therapeutic and diagnostic capabilities. Radioligands, which are radioactively labelled drugs, can target specific receptors, transporters, enzymes, or proteins within the body. This precision targeting allows for highly accurate imaging and treatment of cancer. Clinical trials have shown that FAPI exhibits high uptake in various types of cancer, including gastrointestinal tumours, liver tumours, breast tumours, nasopharyngeal cancer, and bone cancer.

Positron emission tomography (PET) is a cornerstone technology in this research. PET provides detailed molecular imaging, producing comprehensive visualisations that combine functional and structural information about tumors. This advanced imaging technology is crucial for initial diagnosis, treatment evaluation, prognosis, and relapse detection.

The concept of theranostic systems, which apply diagnostic imaging tools to identify specific molecular targets, is central to this research. These systems enable the selection of personalised treatments based on detailed imaging data, ensuring that patients receive the most effective therapy for their specific cancer type.

Through this collaboration, BRIN can learn to use various radioisotopes available in Norway, such as 68Ga and other PET radionuclides. This knowledge transfer can lead to new breakthroughs in the use of radionuclide types for radiopharmaceuticals in Indonesia.

UNN Norway Senior PET IC Researcher, Mathias Kranz, expressed optimism about the potential of FAPI development to initiate broader cooperation between BRIN and UNN. This collaboration represents a significant step forward in utilising advanced digital technology for cancer diagnosis and therapy. By combining the expertise and resources of BRIN and PET-IC UNN, this partnership aims to achieve significant improvements in patient outcomes and advancements in radiopharmaceuticals. The integration of molecular imaging techniques with cutting-edge radiopharmaceutical research holds great promise for the future of cancer treatment, offering new hope to patients worldwide.

Moreover, the incorporation of theranostic systems marks a significant technological advancement. Theranostics combines therapy and diagnostics, using specific imaging agents to identify molecular targets and subsequently delivering targeted treatments. This approach ensures that treatments are tailored to the individual characteristics of each patient’s cancer, potentially improving outcomes and reducing side effects.

The collaboration between BRIN and PET-IC UNN is envisioned to generate valuable data on the effectiveness of various FAPI ligands. This data will be instrumental in optimising these ligands as theranostic agents. The use of radioisotopes like 68Ga, which are not yet widely developed in Indonesia, represents a significant technological leap. By adopting these advanced radioisotopes, Indonesia can enhance its capabilities in radiopharmaceuticals, paving the way for new treatments and diagnostic tools.

PARTNER

Qlik’s vision is a data-literate world, where everyone can use data and analytics to improve decision-making and solve their most challenging problems. A private company, Qlik offers real-time data integration and analytics solutions, powered by Qlik Cloud, to close the gaps between data, insights and action. By transforming data into Active Intelligence, businesses can drive better decisions, improve revenue and profitability, and optimize customer relationships. Qlik serves more than 38,000 active customers in over 100 countries.

PARTNER

As a Titanium Black Partner of Dell Technologies, CTC Global Singapore boasts unparalleled access to resources.

Established in 1972, we bring 52 years of experience to the table, solidifying our position as a leading IT solutions provider in Singapore. With over 300 qualified IT professionals, we are dedicated to delivering integrated solutions that empower your organization in key areas such as Automation & AI, Cyber Security, App Modernization & Data Analytics, Enterprise Cloud Infrastructure, Workplace Modernization and Professional Services.

Renowned for our consulting expertise and delivering expert IT solutions, CTC Global Singapore has become the preferred IT outsourcing partner for businesses across Singapore.

PARTNER

Planview has one mission: to build the future of connected work. Our solutions enable organizations to connect the business from ideas to impact, empowering companies to accelerate the achievement of what matters most. Planview’s full spectrum of Portfolio Management and Work Management solutions creates an organizational focus on the strategic outcomes that matter and empowers teams to deliver their best work, no matter how they work. The comprehensive Planview platform and enterprise success model enables customers to deliver innovative, competitive products, services, and customer experiences. Headquartered in Austin, Texas, with locations around the world, Planview has more than 1,300 employees supporting 4,500 customers and 2.6 million users worldwide. For more information, visit www.planview.com.

SUPPORTING ORGANISATION

SIRIM is a premier industrial research and technology organisation in Malaysia, wholly-owned by the Minister​ of Finance Incorporated. With over forty years of experience and expertise, SIRIM is mandated as the machinery for research and technology development, and the national champion of quality. SIRIM has always played a major role in the development of the country’s private sector. By tapping into our expertise and knowledge base, we focus on developing new technologies and improvements in the manufacturing, technology and services sectors. We nurture Small Medium Enterprises (SME) growth with solutions for technology penetration and upgrading, making it an ideal technology partner for SMEs.

PARTNER

HashiCorp provides infrastructure automation software for multi-cloud environments, enabling enterprises to unlock a common cloud operating model to provision, secure, connect, and run any application on any infrastructure. HashiCorp tools allow organizations to deliver applications faster by helping enterprises transition from manual processes and ITIL practices to self-service automation and DevOps practices. 

PARTNER

IBM is a leading global hybrid cloud and AI, and consulting services provider, helping clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Nearly 3,800 government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently, and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and business services deliver open and flexible options to our clients. All of this is backed by IBM’s legendary commitment to trust, transparency, responsibility, inclusivity, and service. For more information, visit www.ibm.com